Association between vitamin D Deficiency and risk factors in women aged 50 Or Plus

Results of studies carried out showed a strong relationship between vitamin D deficiency and metabolic syndrome in postmenopausal women. The Metabolic syndrome (MetS), a condition when there is heightened risk of heart disease, stroke, and diabetes and it is estimated to affect approximately 50% of the female population above the age of 50 developed countries.

Around 57.8% of the women having MetS were analyzed with vitamin D insufficiency (20-29 nanograms per milliliter of blood) or deficiency (less than 20 ng/ml) and about 39.8% of them with sufficient vitamin D (30 ng/ml or more).

To prove the indication whether or not the patient has MetS, typical parameters for MetS diagnosis were adopted: waist circumference above 88 cm, high blood sugar (fasting glucose above 100 mg/dL), high blood pressure (above 130/85 mmHg), and abnormal levels of triglycerides (above 150 mg/dL) and cholesterol (HDL below 50 mg/dL). if three or more of these criteria were established then the patient was considered as diagnosed with MetS.

Researches done earlier showed the existence of several mechanisms that may explain the effect of vitamin D in contribution to MetS. The best possible explanation for the association between vitamin D deficiency and its risk factors in women is that vitamin D influences insulin secretion and sensitivity, which play a major role in MetS.

Insulin-secreting pancreatic beta cells expressed the vitamin D receptor and in peripheral target tissues such as skeletal muscle and adipose tissue. Vitamin D deficiency can compromise the capacity of beta cells to convert proinsulin to insulin

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